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Improving Factual Completeness and Consistency of Image-to-text Radiology Report Generation

The reference code of Improving Factual Completeness and Consistency of Image-to-text Radiology Report Generation.

Implemented Models

• CNN-RNN-RNN (Liu et al., 2019)
• Knowing When to Look (Lu et al., 2017)
• Meshed-Memory Transformer (Cornia et al., 2020)
• Show, Attend and Tell (Xu et al., 2015)
• TieNet (Wang et al., 2018)

Supported Radiology Report Datasets

• MIMIC-CXR-JPG (Johnson et al., 2019)
• Open-i (Demner-Fushman et al., 2012)

Radiology NLI Dataset

The Radiology NLI dataset (RadNLI) is available at a corresponding PhysioNet project.

Prerequisites

• A Linux OS (tested on Ubuntu 16.04)
• Memory over 24GB
• A gpu with memory over 12GB (tested on NVIDIA Titan X and NVIDIA Titan XP)

Preprocesses

Python Setup

Create a conda environment

$ conda env create -f environment.yml

NOTE : environment.yml is set up for CUDA 10.1 and cuDNN 7.6.3. This may need to be changed depending on a runtime environment.

Resize MIMIC-CXR-JPG

1. Download MIMIC-CXR-JPG
2. Make a resized copy of MIMIC-CXR-JPG using resize_mimic-cxr-jpg.py (MIMIC_CXR_ROOT is a dataset directory containing mimic-cxr)
   • $ python resize_mimic-cxr-jpg.py MIMIC_CXR_ROOT
3. Create the sections file of MIMIC-CXR (mimic_cxr_sectioned.csv.gz) with create_sections_file.py
4. Move mimic_cxr_sectioned.csv.gz to MIMIC_CXR_ROOT/mimic-cxr-resized/2.0.0/

Compute Document Frequencies

Pre-calculate document frequencies that will be used in CIDEr by:

$ python cider-df.py MIMIC_CXR_ROOT mimic-cxr_train-df.bin.gz

Recognize Named Entities

Pre-recognize named entities in MIMIC-CXR by:

$ python ner_reports.py --stanza-download MIMIC_CXR_ROOT mimic-cxr_ner.txt.gz

Download Pre-trained Weights

Download pre-trained CheXpert weights, pre-trained radiology NLI weights, and GloVe embeddings

$ cd resources
$ ./download.sh

Training a Report Generation Model

First, train the Meshed-Memory Transformer model with an NLL loss.

# NLL
$ python train.py --cuda --corpus mimic-cxr --cache-data cache --epochs 32 --batch-size 24 --entity-match mimic-cxr_ner.txt.gz --img-model densenet --img-pretrained resources/chexpert_auc14.dict.gz --cider-df mimic-cxr_train-df.bin.gz --bert-score distilbert-base-uncased --corpus mimic-cxr --lr-scheduler trans MIMIC_CXR_ROOT resources/glove_mimic-cxr_train.512.txt.gz out_m2trans_nll

Second, further train the model a joint loss using the self-critical RL to achieve a better performance.

# RL with NLL + BERTScore + EntityMatchExact
$ python train.py --cuda --corpus mimic-cxr --cache-data cache --epochs 32 --batch-size 24 --rl-epoch 1 --rl-metrics BERTScore,EntityMatchExact --rl-weights 0.01,0.495,0.495 --entity-match mimic-cxr_ner.txt.gz --baseline-model out_m2trans_nll/model_31-152173.dict.gz --img-model densenet --img-pretrained resources/chexpert_auc14.dict.gz --cider-df mimic-cxr_train-df.bin.gz --bert-score distilbert-base-uncased --lr 5e-6 --lr-step 32 MIMIC_CXR_ROOT resources/glove_mimic-cxr_train.512.txt.gz out_m2trans_nll-bs-emexact

# RL with NLL + BERTScore + EntityMatchNLI
$ python train.py --cuda --corpus mimic-cxr --cache-data cache --epochs 32 --batch-size 24 --rl-epoch 1 --rl-metrics BERTScore,EntityMatchNLI --rl-weights 0.01,0.495,0.495 --entity-match mimic-cxr_ner.txt.gz --baseline-model out_m2trans_nll/model_31-152173.dict.gz --img-model densenet --img-pretrained resources/chexpert_auc14.dict.gz --cider-df mimic-cxr_train-df.bin.gz --bert-score distilbert-base-uncased --lr 5e-6 --lr-step 32 MIMIC_CXR_ROOT resources/glove_mimic-cxr_train.512.txt.gz out_m2trans_nll-bs-emnli

Checking Result with TensorBoard

A training result can be checked with TensorBoard.

$ tensorboard --logdir out_m2trans_nll-bs-emnli/log
Serving TensorBoard on localhost; to expose to the network, use a proxy or pass --bind_all
TensorBoard 2.0.0 at http://localhost:6006/ (Press CTRL+C to quit)

Evaluation using CheXbert

NOTE: This evaluation assumes that CheXbert is set up in ./CheXbert.

First, extract reference reports to a csv file.

$ python extract_reports.csv MIMIC_CXR_ROOT/mimic-cxr-resized/2.0.0/mimic_cxr_sectioned.csv.gz MIMIC_CXR_ROOT/mimic-cxr-resized/2.0.0/mimic-cxr-2.0.0-split.csv.gz mimic-imp
$ mv mimic-imp CheXbert/src/

Second, convert generated reports to a csv file. (TEST_SAMPLES is a path to test samples. e.g., out_m2trans_nll-bs-emnli/test_31-152173_samples.txt.gz)

$ python convert_generated.py TEST_SAMPLES gen.csv
$ mv gen.csv CheXbert/src/

Third, run CheXbert against the reference reports.

$ cd CheXbert/src/
$ python label.py -d mimic-imp/reports.csv -o mimic-imp -c chexbert.pth

Fourth, run eval_prf.py to obtain CheXbert scores.

$ cp ../../eval_prf.py .
$ python eval_prf.py mimic-imp gen.csv gen_chex.csv
2947 references
2347 generated
...
5-micro x.xxx x.xxx x.xxx
5-acc x.xxx

Inferring from a Checkpoint

An inference from a checkpoint can be done with infer.py. (CHECKPOINT is a path to the checkpoint)

$ python infer.py --cuda --corpus mimic-cxr --cache-data cache --batch-size 24 --entity-match mimic-cxr_ner.txt.gz --img-model densenet --img-pretrained resources/chexpert_auc14.dict.gz --cider-df mimic-cxr_train-df.bin.gz --bert-score distilbert-base-uncased --corpus mimic-cxr --lr-scheduler trans MIMIC_CXR_ROOT CHECKPOINT resources/glove_mimic-cxr_train.512.txt.gz out_infer

Pre-trained checkpoints for M2 Transformer can be obtained with a download script.

$ cd checkpoints
$ ./download.sh

Make the RadNLI pseudo training data used in the paper

The RadNLI pseudo training data can be made with make_radnli-pseudo-train.py.

$ python make_radnli-pseudo-train.py MIMIC_CXR_ROOT/mimic-cxr-resized/2.0.0/mimic_cxr_sectioned.csv.gz

Licence

See LICENSE and clinicgen/external/LICENSE_bleu-cider-rouge-spice for details.