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Pyro-Velocity
<div align="center" style="margin-left: auto; margin-right: auto; max-width: 540px; overflow-x: auto;"> <a href="https://docs.pyrovelocity.net"> <img src="https://raw.githubusercontent.com/pinellolab/pyrovelocity/main/docs/_static/logo.png" alt="Pyro-Velocity logo" style="width: 300px; max-width: 60%; height: auto; max-height: 350px;" role="img"> </a>𝒫robabilistic modeling of RNA velocity ⬱
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Pyro-Velocity is a library for probabilistic inference in minimal models approximating gene expression dynamics from, possibly multimodal, single-cell sequencing data. It provides posterior estimates of gene expression parameters, predictive estimates of gene expression states, and local estimates of cell state transition probabilities. It can be used as a component in frameworks that attempt to retain the ability to propagate uncertainty in predicting: distributions over cell fates from subpopulations of cell states, response to cell state perturbations, or candidate genes or gene modules that correlate with determination of specific cell fates.
Documentation 📒
Please see the Documentation.
Changelog 🔀
Changes for each release are listed in the Changelog.
Contributing ✨
Please review the Contributing Guide for instructions on setting up a development environment and submitting pull requests.
Community 🏘
If you would like to apply Pyro-Velocity in your research, have an idea for a new feature, have a problem using the library, or just want to chat, please feel free to start a discussion.
If you have a feature request or issue using Pyro-Velocity that may require making changes to the contents of this repository, please file an issue containing
- a GitHub permananent link to the location in the repository you think is causing a problem or will require changes, and
- provide a minimal reproducible example of the problem or proposed improvement.
We are always interested in discussions and issues that can help to improve the Documentation.