Awesome

LEAD-DBS

LEAD-DBS is NOT intended for clinical use!

About Lead-DBS

LEAD-DBS is a MATLAB toolbox facilitating the:

• reconstruction of deep-brain-stimulation (DBS) electrodes in the human brain on basis of postoperative MRI and/or CT imaging
• the visualization of localization results in 2D/3D
• a group-analysis of DBS-electrode placement results and their effects on clinical results
• simulation of DBS stimulations (calculation of volume of activated tissue – VAT)
• diffusion tensor imaging (DTI) based connectivity estimates and fiber-tracking from the VAT to other brain regions (connectomic surgery)

Installation

Prerequisites

• Recommended RAM size: 32GB or more
• MATLAB version: R2022b or later
• The following MATLAB toolboxes
  • MATLAB Image Processing Toolbox
  • MATLAB Signal Processing Toolbox
  • MATLAB Statistics and Machine Learning Toolbox
  • MATLAB Curve Fitting Toolbox (optional)
  • MATLAB Parallel Computing Toolbox (optional)
• The SPM12 toolbox

Normal installation

Lead-DBS can be downloaded from our website in fully functional form.

Development installation

Alternatively, especially in case you wish to modify and contribute to Lead-DBS, you can

• Make sure to meet the prerequisites
• Clone the Lead-DBS repository from github.
• Download the necessary data and unzip it into the cloned git repository.

We’d love to implement your improvements into Lead-DBS – please contact us for direct push access to Github or feel free to add pull-requests to the Lead-DBS repository.

Getting started

You can run Lead-DBS by typing "lead demo" into the Matlab prompt. This will open up the main GUI and a 3D viewer with an example patient. But there's much more to explore. Head over to our website to see a walkthrough tutorial, a manual, some more screenshots and other ressources. There's also a helpline in form of a Slack channel. We would love to hear from you.

Questions

If you have questions/problems when using Lead-DBS, you can checkout our:

• Online manual
• Workthrough videos
• Knowledge base (including methods, cortical/subcortical atlases, connectomes, etc.)
• Support forum
• Auto-invite Slack workspace