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A Type-1 Diabetes simulator implemented in Python for Reinforcement Learning purpose

This simulator is a python implementation of the FDA-approved UVa/Padova Simulator (2008 version) for research purpose only. The simulator includes 30 virtual patients, 10 adolescents, 10 adults, 10 children.

HOW TO CITE: Jinyu Xie. Simglucose v0.2.1 (2018) [Online]. Available: https://github.com/jxx123/simglucose. Accessed on: Month-Date-Year.

Notice: simglucose no longer supports python 3.7 and 3.8, please update to >=3.9 verison. Thanks!

Announcement (08/20/2023): simglucose now supports gymnasium! Check examples/run_gymnasium.py for usage.

AnimationCVGA PlotBG Trace PlotRisk Index Stats
animation screenshotCVGABG Trace PlotRisk Index Stats
<!-- ![Zone Stats](https://github.com/jxx123/simglucose/blob/master/screenshots/zone_stats.png) -->

Main Features

Installation

It is highly recommended using pip to install simglucose, follow this link to install pip.

Auto installation:

pip install simglucose

Manual installation:

git clone https://github.com/jxx123/simglucose.git
cd simglucose

If you have pip installed, then

pip install -e .

If you do not have pip, then

python setup.py install

If rllab (optional) is installed, the package will utilize some functionalities in rllab.

Note: there might be some minor differences between auto install version and manual install version. Use git clone and manual installation to get the latest version.

Quick Start

Use simglucose as a simulator and test controllers

Run the simulator user interface

from simglucose.simulation.user_interface import simulate
simulate()

You are free to implement your own controller, and test it in the simulator. For example,

from simglucose.simulation.user_interface import simulate
from simglucose.controller.base import Controller, Action


class MyController(Controller):
    def __init__(self, init_state):
        self.init_state = init_state
        self.state = init_state

    def policy(self, observation, reward, done, **info):
        '''
        Every controller must have this implementation!
        ----
        Inputs:
        observation - a namedtuple defined in simglucose.simulation.env. For
                      now, it only has one entry: blood glucose level measured
                      by CGM sensor.
        reward      - current reward returned by environment
        done        - True, game over. False, game continues
        info        - additional information as key word arguments,
                      simglucose.simulation.env.T1DSimEnv returns patient_name
                      and sample_time
        ----
        Output:
        action - a namedtuple defined at the beginning of this file. The
                 controller action contains two entries: basal, bolus
        '''
        self.state = observation
        action = Action(basal=0, bolus=0)
        return action

    def reset(self):
        '''
        Reset the controller state to inital state, must be implemented
        '''
        self.state = self.init_state


ctrller = MyController(0)
simulate(controller=ctrller)

These two examples can also be found in examples\ folder.

In fact, you can specify a lot more simulation parameters through simulation:

simulate(sim_time=my_sim_time,
         scenario=my_scenario,
         controller=my_controller,
         start_time=my_start_time,
         save_path=my_save_path,
         animate=False,
         parallel=True)

OpenAI Gym usage

import gym

# Register gym environment. By specifying kwargs,
# you are able to choose which patient or patients to simulate.
# patient_name must be 'adolescent#001' to 'adolescent#010',
# or 'adult#001' to 'adult#010', or 'child#001' to 'child#010'
# It can also be a list of patient names
# You can also specify a custom scenario or a list of custom scenarios
# If you chose a list of patient names or a list of custom scenarios,
# every time the environment is reset, a random patient and scenario will be
# chosen from the list

from gym.envs.registration import register
from simglucose.simulation.scenario import CustomScenario
from datetime import datetime

start_time = datetime(2018, 1, 1, 0, 0, 0)
meal_scenario = CustomScenario(start_time=start_time, scenario=[(1,20)])


register(
    id='simglucose-adolescent2-v0',
    entry_point='simglucose.envs:T1DSimEnv',
    kwargs={'patient_name': 'adolescent#002',
            'custom_scenario': meal_scenario}
)

env = gym.make('simglucose-adolescent2-v0')

observation = env.reset()
for t in range(100):
    env.render(mode='human')
    print(observation)
    # Action in the gym environment is a scalar
    # representing the basal insulin, which differs from
    # the regular controller action outside the gym
    # environment (a tuple (basal, bolus)).
    # In the perfect situation, the agent should be able
    # to control the glucose only through basal instead
    # of asking patient to take bolus
    action = env.action_space.sample()
    observation, reward, done, info = env.step(action)
    if done:
        print("Episode finished after {} timesteps".format(t + 1))
        break

import gym
from gym.envs.registration import register


def custom_reward(BG_last_hour):
    if BG_last_hour[-1] > 180:
        return -1
    elif BG_last_hour[-1] < 70:
        return -2
    else:
        return 1


register(
    id='simglucose-adolescent2-v0',
    entry_point='simglucose.envs:T1DSimEnv',
    kwargs={'patient_name': 'adolescent#002',
            'reward_fun': custom_reward}
)

env = gym.make('simglucose-adolescent2-v0')

reward = 1
done = False

observation = env.reset()
for t in range(200):
    env.render(mode='human')
    action = env.action_space.sample()
    observation, reward, done, info = env.step(action)
    print(observation)
    print("Reward = {}".format(reward))
    if done:
        print("Episode finished after {} timesteps".format(t + 1))
        break

rllab usage

from rllab.algos.ddpg import DDPG
from rllab.envs.normalized_env import normalize
from rllab.exploration_strategies.ou_strategy import OUStrategy
from rllab.policies.deterministic_mlp_policy import DeterministicMLPPolicy
from rllab.q_functions.continuous_mlp_q_function import ContinuousMLPQFunction
from rllab.envs.gym_env import GymEnv
from gym.envs.registration import register

register(
    id='simglucose-adolescent2-v0',
    entry_point='simglucose.envs:T1DSimEnv',
    kwargs={'patient_name': 'adolescent#002'}
)

env = GymEnv('simglucose-adolescent2-v0')
env = normalize(env)

policy = DeterministicMLPPolicy(
    env_spec=env.spec,
    # The neural network policy should have two hidden layers, each with 32 hidden units.
    hidden_sizes=(32, 32)
)

es = OUStrategy(env_spec=env.spec)

qf = ContinuousMLPQFunction(env_spec=env.spec)

algo = DDPG(
    env=env,
    policy=policy,
    es=es,
    qf=qf,
    batch_size=32,
    max_path_length=100,
    epoch_length=1000,
    min_pool_size=10000,
    n_epochs=1000,
    discount=0.99,
    scale_reward=0.01,
    qf_learning_rate=1e-3,
    policy_learning_rate=1e-4
)
algo.train()

Advanced Usage

You can create the simulation objects, and run batch simulation. For example,

from simglucose.simulation.env import T1DSimEnv
from simglucose.controller.basal_bolus_ctrller import BBController
from simglucose.sensor.cgm import CGMSensor
from simglucose.actuator.pump import InsulinPump
from simglucose.patient.t1dpatient import T1DPatient
from simglucose.simulation.scenario_gen import RandomScenario
from simglucose.simulation.scenario import CustomScenario
from simglucose.simulation.sim_engine import SimObj, sim, batch_sim
from datetime import timedelta
from datetime import datetime

# specify start_time as the beginning of today
now = datetime.now()
start_time = datetime.combine(now.date(), datetime.min.time())

# --------- Create Random Scenario --------------
# Specify results saving path
path = './results'

# Create a simulation environment
patient = T1DPatient.withName('adolescent#001')
sensor = CGMSensor.withName('Dexcom', seed=1)
pump = InsulinPump.withName('Insulet')
scenario = RandomScenario(start_time=start_time, seed=1)
env = T1DSimEnv(patient, sensor, pump, scenario)

# Create a controller
controller = BBController()

# Put them together to create a simulation object
s1 = SimObj(env, controller, timedelta(days=1), animate=False, path=path)
results1 = sim(s1)
print(results1)

# --------- Create Custom Scenario --------------
# Create a simulation environment
patient = T1DPatient.withName('adolescent#001')
sensor = CGMSensor.withName('Dexcom', seed=1)
pump = InsulinPump.withName('Insulet')
# custom scenario is a list of tuples (time, meal_size)
scen = [(7, 45), (12, 70), (16, 15), (18, 80), (23, 10)]
scenario = CustomScenario(start_time=start_time, scenario=scen)
env = T1DSimEnv(patient, sensor, pump, scenario)

# Create a controller
controller = BBController()

# Put them together to create a simulation object
s2 = SimObj(env, controller, timedelta(days=1), animate=False, path=path)
results2 = sim(s2)
print(results2)


# --------- batch simulation --------------
# Re-initialize simulation objects
s1.reset()
s2.reset()

# create a list of SimObj, and call batch_sim
s = [s1, s2]
results = batch_sim(s, parallel=True)
print(results)

Run analysis offline (example/offline_analysis.py):

from simglucose.analysis.report import report
import pandas as pd
from pathlib import Path


# get the path to the example folder
exmaple_pth = Path(__file__).parent

# find all csv with pattern *#*.csv, e.g. adolescent#001.csv
result_filenames = list(exmaple_pth.glob(
    'results/2017-12-31_17-46-32/*#*.csv'))
patient_names = [f.stem for f in result_filenames]
df = pd.concat(
        [pd.read_csv(str(f), index_col=0) for f in result_filenames],
        keys=patient_names)
report(df)

Release Notes

08/20/2023

03/10/2021

5/27/2020

9/10/2018

2/26/2018

1/10/2018

1/7/2018

Reporting issues

Shoot me any bugs, enhancements or even discussion by creating issues.

How to contribute

The following instruction is originally from the contribution instructions of sklearn.

The preferred workflow for contributing to simglucose is to fork the main repository on GitHub, clone, and develop on a branch. Steps:

  1. Fork the project repository by clicking on the 'Fork' button near the top right of the page. This creates a copy of the code under your GitHub user account. For more details on how to fork a repository see this guide.

  2. Clone your fork of the simglucose repo from your GitHub account to your local disk:

    $ git clone git@github.com:YourLogin/simglucose.git
$ cd simglucose

  3. Create a feature branch to hold your development changes:

    $ git checkout -b my-feature

    Always use a feature branch. It's good practice to never work on the master branch!

  4. Develop the feature on your feature branch. Add changed files using git add and then git commit files:

    $ git add modified_files
$ git commit

    to record your changes in Git, then push the changes to your GitHub account with:

    $ git push -u origin my-feature

  5. Follow these instructions to create a pull request from your fork. This will email the committers.

(If any of the above seems like magic to you, please look up the Git documentation on the web, or ask a friend or another contributor for help.)