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CoVES

Structure-based scoring and sampling of 'Combinatorial Variant Effects from Structure' (CoVES)

For the accompanying paper see: https://www.biorxiv.org/content/10.1101/2022.10.31.514613v2

Folder Structure & Usage

The respective folders contain example notebooks of how to perform a given analysis.

Supervised fitting of measured combinatorial variants

Unsupervised scoring and generation of combinatorial variants based on residue-preferences

Additional folders:

Requirements

Note: Some scripts are tied to our research compute cluster (Harvard O2 research computing with Slurm Workload Manager), and are provided as reference only.

Please feel free to contact (davidding at berkeley dot edu) or (ayshaw at g dot harvard dot edu) for questions.