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NonCompart-package

Noncompartmental Analysis for Pharmacokinetic Data

Description

It conducts a noncompartmental analysis(NCA) with industrial strength.

Details

The main functions are

• tblNCA to perform NCA for many subjects.
• sNCA to perform NCA for one subject.

Author

Kyun-Seop Bae k@acr.kr

References

• Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.

• Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.

• Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.

• Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.

Examples

# Theoph and Indometh data: dose in mg, conc in mg/L, time in h
tblNCA(Theoph, key="Subject", colTime="Time", colConc="conc", dose=320,
adm="Extravascular", doseUnit="mg", concUnit="mg/L")

tblNCA(Indometh, key="Subject", colTime="time", colConc="conc", dose=25,
adm="Infusion", dur=0.5, doseUnit="mg", concUnit="mg/L", R2ADJ=0.9)

# For individual NCA
iAUC = data.frame(Name=c("AUC[0-12h]","AUC[0-24h]"), Start=c(0,0), End=c(12,24)) ; iAUC

x = Theoph[Theoph$Subject=="1","Time"]
y = Theoph[Theoph$Subject=="1","conc"]

sNCA(x, y, dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h", iAUC=iAUC)
sNCA(x, y, dose=320, concUnit="mg/L", iAUC=iAUC)