Awesome
Protein Design Labs
🤩 Welcome to our curated list of computational protein design research labs!
This list serves as a public reference for labs engaged in computational protein design research. While we've made every effort to be comprehensive, our knowledge may be limited (mostly limited to labs in the US and China).
We apologize if we've missed your lab or labs you're familiar with. Suggestions for additions are highly welcomed – please feel free to open new issues.
📝 Note: The list was based on @Zuricho's post on Zhihu in Chinese. The current version has been expanded and formatted with the assistance of @Leo-T-Zang.
Table of Contents
- #North America
- :us: United States
- MIT
- Harvard University
- Stanford University
- University of Washington
- UCSF
- UC Berkeley
- UCLA
- Caltech
- University of Chicago
- UIUC
- Scripps Research Institute
- Princeton University
- Duke University
- John Hopkins University
- Carnegie Mellon University
- Northwestern University
- UNC Chapel Hill
- St. Jude Children’s Research Hospital
- Dartmouth College
- Columbia University
- New York University
- Northeastern University
- Texas A&M University
- UCSB
- UCSC
- UT Southwestern
- University of Wisconsin-Madison
- University of Alabama at Birmingham
- University of Florida
- Georgia Institute of Technology
- University of Delaware
- Wake Forest University
- Vanderbilt University
- :canada: Canada
- :us: United States
- #EMEA
- #Asia
- :jp: Japan
- :singapore: Singapore
- :kr: South Korea
- :hong_kong: Hong Kong
- :cn: China Mainland
- Peking University 北京大学
- Tsinghua University 清华大学
- CAS ICT 中国科学院计算技术研究所
- CAS IBP 中国科学院生物物理研究所
- Renmin University of China 中国人民大学
- Shanghai Jiao Tong University 上海交通大学
- Fudan University 复旦大学
- ShanghaiTech University 上海科技大学
- CAS SIMM 中国科学院上海药物研究所
- CAS CEMCS 中国科学院分子细胞科学卓越创新中心
- Zhejiang University 浙江大学
- Westlake University 西湖大学
- Zhejiang University of Technology 浙江工业大学
- Sun Yat-sen University 中山大学
- CAS SIAT 深圳先进技术研究院
- Tsinghua SIGS 清华大学深圳国际研究生院
- SUSTech 南方科技大学
- USTC 中国科学技术大学
- Xiamen University 厦门大学
- Shandong University 山东大学
- CAS TIB 中国科学院天津工业生物技术研究所
#North America
:us: United States
MIT
<details> <summary>Bonnie Berger</summary>- Lab website: Link
- Lab website: Link
- Lab website: Link
- Related paper:
- CLIPZyme: arXiv:2402.06748
- Lab website: Link
- Lab website: Link
- Lab website: Link
- Lab website: Link
Harvard University
<details> <summary>Debora Marks & Chris Sander</summary>- Lab websites:
- Related papers: </details>
- Lab website: Polizzi Lab
- Lab website: Link
- Lab website: Link
- Lab website: Link
- Lab website: Link
Stanford University
<details> <summary>Possu Huang</summary>- Lab website: Link
- Lab website: Link
- Lab website: Link
- Lab website: Link
- Lab website: Link
- Lab website: Link
- Lab website: Link
University of Washington
<details> <summary>David Baker</summary>- Lab website: Baker Lab - UW Institute for Protein Design
- Research focus: Protein design
- Lab website: King Lab | Research
- Research focus: Protein nanomaterial design for medicine, self-assembling protein nanomaterial design
- Lab website: Bhardwaj Lab
- Research focus: Peptide design for therapeutics
- Lab website: DiMaio Lab - University of Washington
- Research focus: Protein structure determination from low-resolution experimental data
UCSF
<details> <summary>William DeGrado</summary>- Lab website: Link
- Lab website: Link
UC Berkeley
<details> <summary>Jennifer Doudna</summary>- Lab website: Link
- Personal website: Yun S. Song
- Personal website: Jennifer Listgarten
- Lab website: Link
UCLA
<details> <summary>Quanquan Gu</summary>- Lab website: Link
- Personal website: Quanquan Gu
- Related papers: </details>
- Personal website: Lin Jiang, Ph.D.
Caltech
<details> <summary>Frances Arnold</summary>- Lab website: Link
- Lab website: Welcome to the Mayo Group
- Lab website: Link
University of Chicago
<details> <summary>Rama Ranganathan</summary>- Lab website: Ranganathan Lab
- Related paper:
- Lab website: Ferguson Lab
- Personal website: Andrew Ferguson
- Related paper:
UIUC
<details> <summary>Huimin Zhao</summary>- Lab website: Zhao Group @ UIUC
- Personal website: Ge Liu
Scripps Research Institute
<details> <summary>William E. Balch</summary>- Lab website: Balch Lab
- Lab website: Mravic Lab
Princeton University
<details> <summary>Mengdi Wang</summary>- Lab website: Link
- Lab website: Link
Duke University
<details> <summary>Bruce Donald</summary>- Lab website: Link
- Lab website: Link
- Lab website: Link
- Lab website: Link
- Lab website: Link
- Lab website: Link
John Hopkins University
<details> <summary>Jeffrey J. Gray</summary>- Lab website: Link
Carnegie Mellon University
<details> <summary>Lei Li</summary>Northwestern University
<details> <summary>Gabriel J. Rocklin</summary>- Lab website: Link
- Lab website: Link
- Related Papers:
UNC Chapel Hill
<details> <summary>Brian Kuhlman</summary>- Lab website: Kuhlman Lab
- Personal website: Tianlong Chen
- Personal website: Huaxiu Yao's Personal Website
- Lab website: Link
St. Jude Children’s Research Hospital
<details> <summary>Elizabeth H. Kellogg</summary>- Lab website: link
Dartmouth College
<details> <summary>Gevorg Grigoryan (Left for Company)</summary>- Personal website: Gevorg Grigoryan
Columbia University
<details> <summary>Mohammed AlQuraishi</summary>- Lab website: AlQuraishi Lab at Columbia University
- Lab website: Banta Lab
- Personal website: Anum Glasgow
New York University
<details> <summary>Jin Kim Montclare</summary>- Lab website: Montclare Lab
- Lab website: Link
- Related paper:
- Lab website: Link
Northeastern University
<details> <summary>Wengong Jin</summary>- Personal website: Wengong Jin
Texas A&M University
<details> <summary>Shuiwang Ji</summary>- Personal website: Shuiwang Ji
UCSB
<details> <summary>Yang Yang</summary>- Lab website: Yang Lab at UCSB
UCSC
<details> <summary>Andy Hsien-Wei Yeh</summary>- Lab website: Link
- Related paper: bioRxiv 2023
UT Southwestern
<details> <summary>Qian Cong</summary>- Lab website: Link
University of Wisconsin-Madison
<details> <summary>Anthony Gitter</summary>- Lab website: Link
University of Alabama at Birmingham
<details> <summary>Hy Truong Son</summary>- Lab website: Link
University of Florida
<details> <summary>Wenjun Xie</summary>- Lab website: Link
Georgia Institute of Technology
<details> <summary>Yunan Luo</summary>- Lab website: Link
University of Delaware
<details> <summary>Jason Gleghorn</summary>- Lab website: Link
Wake Forest University
<details> <summary>Katherine I. Albanese</summary>- Lab website: Link
Vanderbilt University
<details> <summary>Zhongyue Yang</summary>- Lab website: Link
- Lab website: Link
- Lab website: Link
- Lab website: Link
- Lab website: Link
- Lab website: Link
:canada: Canada
Mila - Quebec AI Institute
<details> <summary>Yoshua Bengio</summary>- Lab website: Link
- Lab website: Link
University of Toronto
<details> <summary>Philip M. Kim</summary>- Lab website: Link
#EMEA
:uk: United Kingdom
University of Cambridge
<details> <summary>Pietro Liò</summary>- Lab website: Link
University of Oxford
<details> <summary>Michael Bronstein</summary>- Lab website: Link
- Lab website: OPIG
- Lab website: Yarin Gal - Home Page | Oxford Machine Learning
Imperial College London
<details> <summary>Guang Yang</summary>- Lab website: link
UCL
<details> <summary>David T. Jones</summary>- Lab website: Link
University of Edinburgh
<details> <summary>Chris Wells Wood</summary>- Lab website: Link
- Lab website: Link
University of Bristol
<details> <summary>Dek Woolfson</summary>- Lab website: Link
- Lab website: Link
Cardiff University
<details> <summary>Fabio Parmeggiani</summary>- Lab website: Link
- Related papers:
University of Leeds
<details> <summary>Darren Tomlinson</summary>- Lab website: Link
- Lab website: Link
- Lab website: Link
- Lab website: Link
- Lab website: Link
- Lab website: Link
:ireland: Ireland
University College Cork
<details> <summary>Sabin Tabirca</summary>- Lab website: Link
:switzerland: Switzerland
ETH Zurich
<details> <summary>Donald Hilvert</summary>- Lab website: Hilvert Lab
- Related paper: Design from peptide
EPFL
<details> <summary>Bruno E. Correia</summary>- Lab website: Link
- Lab website: Bitbol Lab
:de: Germany
TUM
<details> <summary>Rost Burkhard</summary>- Lab website: Rost Lab
FU Berlin
<details> <summary>Frank Noé</summary>- Lab website: Link
Leipzig University
<details> <summary>Clara T. Schoeder</summary>- Lab website: Link
- Related paper:
University of Bayreuth
<details> <summary>Birte Höcker</summary>- Lab website: Link
:fr: France
Ecole Polytechnique
<details> <summary>Thomas Simonson</summary> </details>INRAE MIAT
<details> <summary>Thomas Schiex</summary>- Lab website: Link
Toulouse Biotechnology Institute
<details> <summary>Sophie Barbe</summary> </details>:es: Spain
Centre for Genomic Regulation
<details> <summary>Noelia Ferruz</summary>- Lab website: Artificial Intelligence for Protein Design - Noelia Ferruz lab
- Related paper:
IBMB CSIC
<details> <summary>Enrique Marcos</summary>- Lab website: Link
- Related paper:
IMDEA Nanoscience research institute
<details> <summary>Sara H Mejias</summary>- Lab website: Link
Barcelona Supercomputing Center
<details> <summary>Victor Guallar Tasies</summary>- Lab website: Link
Spanish National Research Council
<details> <summary>Manuel Ferrer Martínez</summary>- Lab website: Link
Universitat Autònoma de Barcelona
<details> <summary>Salvador Ventura Zamora</summary>- Lab website: Link
:austria: Austria
TU Graz
<details> <summary>Gustav Oberdorfer</summary>- Lab website: Link
- Related Paper:
:belgium: Belgium
Vrije Universiteit Brussel
<details> <summary>Anastassia A. Vorobieva</summary>- Lab website: Link
- Related papers:
:sweden: Sweden
Stockholm University
<details> <summary>Patrick Bryant</summary>- Lab website: Link
- Related papers:
:denmark: Denmark
University of Copenhagen
<details> <summary>Kresten Lindorff-Larsen</summary>- Lab website: Link
- Related papers:
- Lab website: Link
- Related papers:
Aarhus University
<details> <summary>Michael Westberg</summary>- Lab website: Link
:israel: Israel
Weizmann Institute of Science
<details> <summary>Sarel J Fleishman</summary>- Lab website: Link
- Related papers:
Tel Aviv University
<details> <summary>Jérôme Tubiana</summary>- Lab website: Link
🇸🇦 Saudi Arabia
KAUST
<details> <summary>Xin Gao</summary>- Lab website: Link
Mohamed bin Zayed University of AI
<details> <summary>Eric Xing</summary>- Lab website: Link
🇳🇱 Netherlands
Eindhoven University of Technology
<details> <summary>Francesca Grisoni</summary>- Lab website: Link
Czech Republic
Masaryk University
<details> <summary>Jiri Damborsky</summary>- Lab website: Link
#Asia
:jp: Japan
Tokyo University
<details> <summary>Kotaro Tsuboyama</summary>- Lab website: Link
- Related papers:
:singapore: Singapore
National University of Singapore
<details> <summary>Yang Zhang</summary>- Research focus: Structure prediction
- Lab website: The Yang Zhang Lab
- Related papers:
:kr: South Korea
Seoul National University
<details> <summary>Martin Steinegger</summary>- Lab website: Link
- Lab website: Link
KAIST
<details> <summary>Ji-Joon Song</summary>- Lab website: Link
- Lab website: Link
POSTECH
<details> <summary>Sangmin Lee</summary>- Lab website: Link
IBS
<details> <summary>Ho Min Kim</summary>- Lab website: Link
:hong_kong: Hong Kong
Chinese University of Hong Kong
<details> <summary>Yu Li</summary>- Lab website: Link
- Related Paper:
HKUST
<details> <summary>Danqing Zhu</summary>- Lab website: Link
- Related Paper
:cn: China Mainland
Peking University 北京大学
<details> <summary>Luhua Lai 来鲁华</summary>- Lab website: Link
- Related Papers:
- [Angew 2024] GeoSeqBuilder: https://onlinelibrary.wiley.com/doi/10.1002/anie.202411461
- Lab website: Link
- Lab website: Link
- Lab website: Link
- Related Papers:
- [ACL 2024] ProtLLM: ProtLLM: An Interleaved Protein-Language LLM with Protein-as-Word Pre-Training
Tsinghua University 清华大学
<details> <summary>Haipeng Gong 龚海鹏</summary>- Lab website: Link
- Related Papers:
- [NatComm 2024] SPIRED: https://www.nature.com/articles/s41467-024-51776-x
- Lab website: Link
- Related Papers:
- [Nature 2020] Transmembrane pore design: https://www.nature.com/articles/s41586-020-2646-5
- Lab website: Link
- Related Papers:
- [NeurlPS 2022] DiffAb: https://www.biorxiv.org/content/10.1101/2022.07.10.499510.abstract
- Lab website: Link
- Related Papers:
- [ICLR 2023] Antibody design: https://arxiv.org/abs/2208.06073
- Lab website: Link
- Lab website: Link
- Related Papers:
- [ICML 2024] ESM-AA: https://arxiv.org/abs/2403.12995
CAS ICT 中国科学院计算技术研究所
<details> <summary>Dongbo Bu 卜东波</summary>- Lab website: Link
- Related Papers:
- [Nature Machine Intelligence 2024] CarbonDesign: https://www.nature.com/articles/s42256-024-00838-2
- Lab website: Link
- Related Papers:
- [Nature Machine Intelligence 2024] CarbonDesign: https://www.nature.com/articles/s42256-024-00838-2
CAS IBP 中国科学院生物物理研究所
<details> <summary>Xianen Zhang 张先恩</summary>- Lab website: Link
- Related Papers:
- Related Papers:
Renmin University of China 中国人民大学
<details> <summary>Wenbing Huang 黄文炳</summary>- Lab website: Link
- Related Papers:
Shanghai Jiao Tong University 上海交通大学
<details> <summary>Liang Hong 洪亮</summary>- Lab website: Link
- Related Papers:
- Lab website: Link
- Related Papers:
- Lab website: Link
- Lab website: Link
- Lab website: Link
- Lab website: Link
- Related Papers:
- [NatComm 2024] QTY code: https://www.nature.com/articles/s41467-024-48513-9, [Chem Rev 2023] Review: https://pubs.acs.org/doi/full/10.1021/acs.chemrev.1c00757
- Lab website: Link
- Related Papers:
- [NeurIPS 2023] GraDe-IF: https://arxiv.org/abs/2306.16819
Fudan University 复旦大学
<details> <summary>Siqi Sun 孙思琦</summary>- Lab website: Link
- Lab website: Link
- Related Papers:
ShanghaiTech University 上海科技大学
<details> <summary>Jiayi Dou 豆佳宜</summary>- Lab website: Link
- Related Papers:
- [Nature 2018] β-barrel design: https://www.nature.com/articles/s41586-018-0509-0
- Lab website: Link
CAS SIMM 中国科学院上海药物研究所
<details> <summary>Mingyue Zheng 郑明月</summary>- Lab website: Link
CAS CEMCS 中国科学院分子细胞科学卓越创新中心
<details> <summary>Shaoqing Zhang 张少庆</summary>- Lab website: Link
- Related Papers:
- [JACS 2018] 设计含有金属离子簇的蛋白:https://pubs.acs.org/doi/10.1021/jacs.7b08261
Zhejiang University 浙江大学
<details> <summary>Tingjun Hou 侯廷军</summary>- Lab website: Link
Westlake University 西湖大学
<details> <summary>Fajie Yuan 原发杰</summary>- Lab website: Link
- Related Papers:
- [ICLR 2024] SaProt: https://www.biorxiv.org/content/10.1101/2023.10.01.560349.abstract
- Lab website: Link
- Related Papers:
- [Nature 2022] RifGen/RifDock: https://www.nature.com/articles/s41586-022-04654-9, [Science 2020] SARS-CoV-2 minibinder design: https://www.science.org/doi/full/10.1126/science.abd9909
- Lab website: Link
- Related Papers:
- [Science 2020] Logic gate design: https://www.science.org/doi/full/10.1126/science.aay2790, [Nature 2019] Orthogonal protein heterodimers design: https://www.nature.com/articles/s41586-018-0802-y
- Lab website: Link
- Related Papers:
- [Science 2018] Transmembrane protein design: https://www.science.org/doi/full/10.1126/science.aaq1739
- Lab website: Link
- Lab website: Link
- Related Papers:
- [ICLR 2023] PiFold: https://arxiv.org/abs/2209.12643
Zhejiang University of Technology 浙江工业大学
<details> <summary>Guijun Zhang 张贵军</summary>- Lab website: Link
Sun Yat-sen University 中山大学
<details> <summary>Yuedong Yang 杨跃东</summary>- Lab website: Link
CAS SIAT 深圳先进技术研究院
<details> <summary>Xiaozhou Luo 罗小舟</summary>- Lab website: Link
Tsinghua SIGS 清华大学深圳国际研究生院
<details> <summary>Feiran Li 李斐然</summary>- Lab website: Link
- Related Papers: [
- Nat Catalysis] DLKcat: https://www.nature.com/articles/s41929-022-00798-z
SUSTech 南方科技大学
<details> <summary>Zhe Li 李喆</summary>- Lab website: Link
- Related Papers:
- [Nat Materials] 蛋白质晶体设计:https://www.nature.com/articles/s41563-023-01683-1
USTC 中国科学技术大学
<details> <summary>Haiyan Liu 刘海燕</summary>- Lab website: Link
- Related Papers:
- [Nature Computational Science 2024] ABACUS-R: https://www.nature.com/articles/s43588-022-00273-6, [Nature 2022] SCUBA: https://www.nature.com/articles/s41586-021-04383-5
- Lab website: Link
- Related Papers:
- [NeurIPS 2023] FAIR: https://arxiv.org/abs/2310.02553
Xiamen University 厦门大学
<details> <summary>Xiaoping Min 闵小平</summary> </details>Shandong University 山东大学
<details> <summary>Jianyi Yang 杨建益</summary>- Lab website: Link
CAS TIB 中国科学院天津工业生物技术研究所
<details> <summary>Huifeng Jiang 江会锋</summary>- Lab website: Link
- Related Papers: